Porosity in hydrogel dressings can enhance tissue contacts and fluid exchanges, although the same property that enables effective transport may also expedite bioactive molecule depletion. This work investigates whether covalent immobilization of an angiopoietin-1-derived peptide sequence QHREDGS can keep an angiogenic signal within a GelMA/HAMA wound patch with structural characteristics and degradability necessary for skin regeneration. A photocrosslinkable mixture of 15\% (w/v) GelMA, 5\% (w/v) HAMA, 1\% (w/v) HMPP, and 2\% sodium alginate was extruded into circular lattices with a diameter of about 15 mm, cured by UV illumination at 365 nm and 10 mW cm$^{-2}$ for 5 min, and modified by the EDC/NHS-based coupling of QHREDGS. Mechanical behavior, lattice structure, degradation rate, FITC-peptide retention, cytocompatibility, scratch and tube formation assays, and hemolytic testing of the material were performed, as well as in vivo tests using a rat full-thickness wound model. The printed structure had an open porous architecture, spongy inner structure and degraded by approximately 51.4\% in 2 U mL$^{-1}$ collagenase II within seven days. Fluorescent labeling confirmed quick peptide disappearance from physical adsorption, especially in thin filaments, and the significantly higher retention of the covalently anchored peptides throughout the entire observation period. Both the extract from the printed hydrogel and that from the hydrogel with coupled peptides demonstrated high cytocompatibility and the latter increased migration of fibroblasts and tube formation of human umbilical vein endothelial cells. Wound patch treatment with the covalent peptide-functionalized lattice resulted in the fastest wound healing, the best regenerated tissue development, less IL-6 and TNF-$\alpha$ staining, stronger collagen deposition, and the highest CD31/$\alpha$-SMA-positive vascular density. The results obtained provide evidence that the therapeutic effect is not due to the presence of hydrogel itself but to its combined properties such as porosity, degradability and angiogenic signal delivery.

GelMA,HAMA,QHREDGS,peptide immobilization,printed hydrogel,angiogenesis,collagenase degradation,wound healing,tissue repair